Table 2.
Sociodemographic and clinical characteristics according to the genotype.
| Variables | ABCB1 C1236T Polymorphism | ABCB1 C3435T Polymorphism | ABCB1 G2677TA Polymorphism | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CC | CT | TT | p Value | CC | CT | TT | p Value | GG | GT | GA | TT | TA | p Value | |
| Age (mean and SD) | 40.6 (10.5) | 41.0 (11.4) | 38.5 (12.3) | 0.807 | 43.0 (10.7) | 40.1 (11.5) | 37.1 (10.0) | 0.246 | 41.3 (10.7) | 40.2 (11.6) | 49.0 | 38.0 (10.5) | 38.3 (15.9) | 0.867 |
| Sex, female (%) | 18 (56.2) | 31 (83.8) | 10 (90.9) | 0.013 | 14 (53.2) | 30 (76.9) | 15 (100) | 0.004 | 18 (56.3) | 30 (83.3) | 0 (0) | 8 (100) | 3 (100) | 0.009 |
| Number of previous depressive episodes | 1.3 (0.5) | 1.5 (0.5) | 1.5 (0.5) | 0.299 | 1.4 (0.5) | 1.5 (0.5) | 1.5 (0.5) | 0.719 | 1.3 (0.5) | 1.6 (0.5) | 1.0 | 1.5 (0.5) | 1.3 (0.6) | 0.400 |
| Time to remission (weeks), mean (SD) | 16.2 (12.1) | 20.0 (11.3) | 10.5 (7.1) | 0.102 | 14.9 (12.3) | 21.3 (10.9) | 10.2 (6.9) | 0.027 # | 15.6 (12.1) | 18.9 (11.0) | 16.0 | 10.0 (7.0) | 31.0 (6.2) | 0.096 |
| Time to relapse (weeks) mean (SD) | 30.6 (13.8) | 45.7 (25.2) | 19.7 (17.9) | 0.177 | 34.8 (12.1) | 31.7 (16.9) | 37.0 (37.6) | 0.930 | 30.6 (13.8) | 44.9 (23.1) | ND | 9.5 (4.9) | ND | 0.077 |
| Total time in the study (weeks) mean (SD) | 59.7 (30.5) | 67.3 (28.4) | 54.3 (33.1) | 0.359 | 34.6 (6.8) | 26.1 (4.2) | 30.1 (7.8) | 0.312 | 62.8 (32.6) | 64.8 (28.5) | 95.0 | 47.6 (28.2) | 59.9 (5.6) | 0.497 |
| Baseline BDI score, mean (SD) | 29.2 (7.6) | 27.4 (6.8) | 25.3 (8.4) | 0.276 | 29.5 (7.9) | 27.6 (6.94) | 25.6 (7.4) | 0.265 | 28.8 (7.6) | 27.9 (7.2) | 24.0 | 24.5 (8.9) | 26.3 (2.5) | 0.647 |
| Final BDI score, mean (SD) | 16.1 (14.3) | 13.0 (10.6) | 13.6 (13.2) | 0.535 | 16.6 (15.2) | 12.9 (12.7) | 14.4 (12.5) | 0.497 | 15.8 (14.6) | 13.9 (10.6) | 1.0 | 12.1 (13.1) | 16.0 (12.2) | 0.762 |
| BDI change, mean (SD) | 12.9 (11.1) | 14.4 (11.1) | 11.6 (8.7) | 0.720 | 12.8 (11.5) | 14.7 (10.4) | 11.0 (10.3) | 0.501 | 13.0 (11.2) | 14.0 (11.1) | 23.0 | 12.4 (8.4) | 10.3 (10.4) | 0.872 |
p value: ANOVA test; # Independent-samples Kruskal-Wallis test.