Table 1.

List of the selected candidate epigenetic regulators of AIS progression.

Gene Symbol	Gene Name	Ref.
ADIPOQ-	Adiponectin, C1Q, and collagen domain containing	[12]
APC-	APC, WNT signaling pathway regulator	[27]
AXIN1-	Axin 1	[14]
COMP-	Cartilage oligomeric matrix protein	[17]
CRTC1-	CREB-regulated transcription coactivator 1	[13]
CTNNB1-	catenin beta 1	[14]
DKK1-	Dickkopf WNT signaling pathway inhibitor 1	[14]
ESR1-	Estrogen receptor 1	[15]
ESR2-	Estrogen receptor 2	[28]
FBN1-	Fibrillin 1	[29]
FBN2-	Fibrillin 2	[29]
FGF4-	Fibroblast growth factor 4	[30]
FRZB-	Frizzled-related protein	[14]
FZD1-	Frizzled class receptor 1	[14]
GREM1-	Gremlin 1, DAN family BMP antagonist	[31]
GSK3B-	Glycogen synthase kinase 3 beta	[14]
H19-	Imprinted maternally expressed transcript (non-protein coding)	[12]
HAS2-	Hyaluronan synthase 2	[16]
LRP5-	LDL receptor related protein 5	[14]
LRP6-	LDL receptor related protein 6	[14]
MSTN-	Myostatin	[12]
MYH3-	Myosin, heavy chain 3, skeletal muscle, embryonic	[12]
NPY-	Neuropeptide Y	[14]
PCDH10-	Protocadherin 10	[18]
PITX1-	Paired-like homeodomain 1	[18]
SOX9-	SRY-box 9	[32]
WNT10A-	Wnt family member 10A	[14]
WNT1-	Wnt family member 1	[14]