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The YRLL motif in PRV gD drives antibody-independent, spontaneous endocytosis of gD in infected PK15 cells. At 5 h postinoculation with wild-type PRV (A) or PRV-gD-YRLA (B), PK15 cells were subjected to a biotinylation assay as described in the text. Lane T, total amount of biotinylated cell surface gD; lane 0′, remaining biotinylated gD after immediate glutathione treatment; lane 60′, amount of glutathione-resistant gD (i.e., endocytosed gD) after 1 h of incubation at 37°C.
