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. 2024 Feb 26;14(5):2228–2246. doi: 10.1016/j.apsb.2024.02.017

Figure 5.

Figure 5

Combined nanoparticles fail to provide protection against NASH at a relatively low dose. (A) Representative liver sections stained with H & E, Oil Red O, and Masson's trichrome in mice from various groups (Chow + MSN, NASH + MSN, NASH + O@MSN, NASH + ON@MSN, and NASH + ONL@MSN). A dose of 0.3 mg/kg was administered in these experiments. Scale bar = 200 μm. (B) Statistical parameters for steatosis, hepatocyte ballooning, lobular inflammation, and the calculated NAFLD activity score (NAS). n = 6 per group. (C) Quantification of lipid accumulation in the liver through Oil Red O staining. n = 6 per group. (D) Quantification of liver fibrosis via Masson's staining. n = 6 per group. (E) Quantitative analysis of the gene expression of pro-inflammatory factors (Tnf-α and Il1β) in the liver of mice treated with nanoparticles. n = 4 per group. Data are presented as mean ± SEM and analyzed using one-way ANOVA followed by Tukey's analysis. NS, no significance.