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. 2024 Feb 26;14(5):2228–2246. doi: 10.1016/j.apsb.2024.02.017

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© 2024 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Bulk-tissue RNA sequencing reveals the effects of ONL@MSN on the liver tissue transcriptome in NASH mice. (A) The experimental design involved performing bulk-tissue RNA sequencing on liver tissues from mice treated with ONL@MSN or MSN (control). (B) The correlation between samples from the two groups was assessed. (C) A volcano plot was generated to display the upregulated DEGs (n = 163) and downregulated DEGs (n = 199) in the liver tissue of mice treated with ONL@MSN compared to mice treated with MSN. (D) A heatmap plot was generated to show the top 20 upregulated and downregulated DEGs, respectively. (E) A KEGG plot was created to illustrate the main processes altered by ONL@MSN compared to MSN in terms of molecular function (MF), biological process (BP), and cell component (CC). (F) A gene interaction network cluster plot was generated to display the major important modules interacting with other genes. (G) A Gene Set Enrichment Analysis (GSEA) plot was generated to demonstrate several enriched signaling pathways resulting from the treatment of ONL@MSN compared to MSN.