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PPT mutations used in this studya
| Mutation | Sequence |
|---|---|
| −15+1LTR | |
| WT PPT | AAAAGAAAAGGGGGGACTGGAAGG |
| 6Gs | TCATACCATGGGGGGACTGGAAGG |
| 4Cs | AAAAGAAAAGGCCCCACTGGAAGG |
| PPTSUB | TCATACCATACTTCCACTGGAAGG |
| ATT SITE | AAAAGAAAAGGGGGGTAGATCCCG |
| 6Cs | AAAAGAAAACCCCCCACTGGAAGG |
Some of the mutations tested in the in vitro assay were introduced into the NL4-3KFSΔnef plasmid. Changes from the WT PPT sequence (shown in bold) are underlined.
