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Inhibition of coronavirus replicative function by cinanserin and cinanserin hydrochloride. BHK-Rep-1 cells containing HCoV-229E-based replicon RNA that mediates GFP expression were used to assess the inhibitory effect of the compounds by FACS analysis and fluorescence microscopy. One representative experiment out of four is shown. Bars indicate GFP-expressing BHK-Rep-1 cells in FACS analyses. The GFP expression of untreated cells was set at 100%.
