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. 2024 May 10;25(10):5215. doi: 10.3390/ijms25105215

Figure 4.

Figure 4

Leptin upregulates AQP1 expression through the Ob-R/STAT3 pathway in human breast cancer cells. (A) Co-expression of leptin and AQP1 mRNA was analyzed using the TCGA database. (B) AQP1 mRNA expression was confirmed by RT-PCR in breast cancer cells treated with leptin for 24 h. Western blot was performed using specific antibodies in MDA-MB-231 cells (C,E,G) and Hs 578T cells (D,F,H) treated with leptin alone (C,D), leptin with and without Ob-R BP (E,F), or leptin with and without AG490 (G,H) for 24 h.