FIG. 2.

Conformational structure of 2D7 epitope on CCR5. The peptide sequences of four specific 2D7-binding phage clones (Fig. 1) from panning round IV were identical. Alignment of the phage-displayed peptide motif with CCR5 ECL-2 identified two regions of homology underlined in the depicted 2D7-2SK peptide sequence. The thread model of human CCR5 is adapted from Siciliano et al. (20). The highlighted amino acids are positions that differ between the human and primate CCR5 proteins.