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. 2024 May 11;25(10):5242. doi: 10.3390/ijms25105242

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Selecting the optimum MMP13 siRNA: (A) the illustration of OA progress by MMP13-induced inflammation and Col2 degradation cycle and the role of siRNAs to inhibit the progression of OA; (B) evaluation of the inhibitory activities of siRNA #1, siRNA #2, and siRNA #3 against MMP13; (C) concentration-dependent inhibitory efficacy of siRNA #3 against MMP13. (Values are presented as mean ± SD (n = 3), and statistical significance was obtained with one-way analysis of ANOVA with Tukey’s multiple comparison post-test (n.s. > 0.05; * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001).)

Selecting the optimum MMP13 siRNA: (A) the illustration of OA progress by MMP13-induced inflammation and Col2 degradation cycle and the role of siRNAs to inhibit the progression of OA; (B) evaluation of the inhibitory activities of siRNA #1, siRNA #2, and siRNA #3 against MMP13; (C) concentration-dependent inhibitory efficacy of siRNA #3 against MMP13. (Values are presented as mean ± SD (n = 3), and statistical significance was obtained with one-way analysis of ANOVA with Tukey’s multiple comparison post-test (n.s. > 0.05; * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001).)