Table 2.
Association of total sitting time and physical activity level with all-cause mortality among US skin cancer survivors and non-cancer adults aged 50 years or older, NHANES 2007–2019
| Death/No. | Weighted death (%) | Hazard Ratio (95% CI) |
|||
|---|---|---|---|---|---|
| Age-adjusteda | MV model 1a,b | MV model 2a,b,c | |||
|
| |||||
| Skin Cancer Survivors | |||||
| Total Sitting Time, h/d | |||||
| <6 | 75/346 | 442529 (13.8) | 1 [reference] | 1 [reference] | 1 [reference] |
| 6–8 | 79/333 | 476866 (15.6) | 1.04 (0.71 to 1.50) | 1.03 (0.71 to 1.51) | 1.03 (0.71 to 1.51) |
| >8 | 53/183 | 325918 (18.4) | 1.73 (1.13 to 2.65) | 1.77 (1.16 to 2.70) | 1.72 (1.11 to 2.67) |
| per 1 h/d increase | NA | NA | 1.07 (1.01 to 1.14) | 1.08 (1.02 to 1.15) | 1.08 (1.01 to 1.15) |
| Physical Activity Level | |||||
| Inactive | 135/454 | 798621 (21.5) | 1 [reference] | 1 [reference] | 1 [reference] |
| Active | 72/408 | 446692 (10.3) | 0.52 (0.37 to 0.74) | 0.66 (0.45 to 0.98) | 0.69 (0.47 to 1.00) |
| Insufficient Active | 22/129 | 114580 (9.1) | 0.43 (0.25 to 0.71) | 0.53 (0.31 to 0.90) | 0.55 (0.31 to 0.97) |
| Physically Active | 50/278 | 332112 (10.9) | 0.57 (0.38 to 0.85) | 0.74 (0.47 to 1.15) | 0.75 (0.49 to 1.15) |
| Non-Cancer Adults | |||||
| Total Sitting Time, h/d | |||||
| <6 | 878/7226 | 5422310 (9.4) | 1 [reference] | 1 [reference] | 1 [reference] |
| 6–8 | 640/4003 | 4287795 (11.4) | 1.24 (1.09 to 1.42) | 1.28 (1.12 to 1.46) | 1.24 (1.08 to 1.42) |
| >8 | 452/2462 | 3532486 (13.3) | 1.72 (1.48 to 1.99) | 1.83 (1.57 to 2.13) | 1.74 (1.50 to 2.03) |
| per 1 h/d increase | NA | NA | 1.07 (1.06 to 1.09) | 1.08 (1.06 to 1.10) | 1.07 (1.06 to 1.09) |
| Physical Activity Level | |||||
| Inactive | 1490/8385 | 9927965 (15.0) | 1 [reference] | 1 [reference] | 1 [reference] |
| Active | 480/5306 | 3314626 (5.9) | 0.47 (0.41 to 0.54) | 0.56 (0.49 to 0.65) | 0.60 (0.52 to 0.69) |
| Insufficient Active | 209/1991 | 1373957 (6.8) | 0.52 (0.44 to 0.63) | 0.61 (0.47 to 0.81) | 0.64 (0.53 to 0.78) |
| Physically Active | 271/3315 | 1940669 (5.5) | 0.44 (0.37 to 0.52) | 0.43 (0.33 to 0.57) | 0.56 (0.47 to 0.67) |
Adjusted for age (years)
Multivariable (MV) model additionally adjusted for sex (male or female), race/ethnicity (Non-Hispanic White and other than Non-Hispanic White), education attainment (less than high school, high school graduate, above high school), family poverty ratio (<1.30, 1.30–3.49, or ≥3.5), body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) (<18.5, 18.5–24.9, 25–29.9, and ≥30), smoking status (never, former, and current), alcohol use (never, former, and current), Healthy Eating Index-2015
Additionally adjusted for hypertension (yes or no), hypercholesterolemia (yes or no), history of diabetes (yes or no), history of CVD (yes or no), years after first diagnosis of cancer, and skin cancer type (melanoma, non-melanoma, unknown)