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Left: CryoET acquires tilt series of 2D projection images of vitrified biological samples over a limited angular range. Right: Simulations of the widely used Shepp-Logan phantom model show that restricted projection angles result in a missing wedge in Fourier space, leading to distortions in the reconstructed image (top row). The objective of this study is to reconstruct the uncollected data in this region, effectively completing the wedge (bottom row).
