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. 2024 May 17;25(10):5489. doi: 10.3390/ijms25105489
AbTACs Antibody-based PROTACs
AURKs Aurora kinases
AUTOTAC Autophagy-targeting chimera
BBB Blood–brain barrier
BTK Bruton tyrosine kinase
c-MET Cellular mesenchymal-to-epithelial transition factor
CNS Central nervous system
CRBN Cereblon
CLL Chronic lymphocytic leukemia
CSF-1R Colony-stimulating factor 1 receptor
CR Complete response
dTAGs Degradation tags
DC Dendritic cell
DOR Duration of response
EFS Event-free survival
EGFR Epidermal growth factor receptor
eTPD Extracellular targeted protein degradation
FGFRs Fibroblast growth factor receptors
HyT-PD Hydrophobic tagging-based protein degradation
ICIs Immune checkpoint inhibitors
IGF-1R Insulin-like growth factor 1 receptor
IND Investigational New Drug
LYTACs Lysosome-targeting chimeras
LTR Lysosome-targeting receptor
mAbs Monoclonal antibodies
NMPA National Medical Products Administration
NEK7 NIMA-related kinase 7
ORR Overall response rate
AKT Protein kinase B
POI Protein of interest
PKIIs Protein–kinase interaction inhibitors
PPI Protein–protein interaction
PPIs Protein–protein interactions
PROTACs Proteolysis-targeting chimeras
RET Proto-oncogene tyrosine protein kinase receptor
ROR1 Receptor tyrosine kinase-like orphan receptor 1
RTKs Receptor tyrosine kinases
ROS1 ROS proto-oncogene 1
SMKIs Small-molecule kinase inhibitors
TPD Targeted protein degradation
TRK Tropomyosin receptor kinase
TME Tumor microenvironment
TAMs Tumor-associated macrophages
FDA U.S. Food and Drug Administration
UC Urothelial carcinoma