Table 1.
General characteristics of the included studies with detailed information about the subjects and intervention methods.
| Author/Date | Tumor\ Therapy |
Sample Size |
Comparison Group | Type of PBM Device | Wavelength | Energy Density | PBM Duration | Power | Irradiation Points |
Timing |
|---|---|---|---|---|---|---|---|---|---|---|
| Silva et al., 2015 [19] | Hematologic malignancies \High-dose chemotherapy, with or without radiation therapy. |
30 patients |
None | InGaAIP | 660 nm | 4 J/cm2 | 4.0 s per point |
40 mW | “The tip touched the mucosa of the lips, right and left buccal mucosa, right and left lateral tongue, ventral tongue, and buccal floor, giving 10 points per region.” |
“Subjects received the PBM from the first day of the conditioning regimen and continued every day, until D+7.” |
| Oton-Leite et al., 2015 [20] | Head and neck cancer\ Chemoradiotherapy. |
25 patients |
Placebo | InGaAlP diode laser | 660 nm | 6.2 J/cm2 | 10 s at each point | 25 mW | “Buccal mucosa [10 points on each side], lips [8 points on upper and lower internal mucosa], hard palate [3 points], lateral tongue [10 points on each side], dorsal tongue [3 points], soft palate [3 points], floor of the mouth [2 points], and in the labial commissure [one point on each side].” | “The first session was performed on the first day of RT, and the following sessions occurred three times a week on alternate days, always before each session of RT, until the end of the treatment.” |
| Salvador et al., 2017 [21] | Hematologic malignancies \High-dose chemotherapy, with or without radiation therapy. |
51 patients |
Only the oral hygiene guidelines |
InGaAlP | 660 nm | 4 J/cm2 | 4.0 s per point |
40 mW | “A total of 10 points were spread over the upper and lower labial mucosa, right and left buccal mucosa, right and left lateral tongue, ventral of the tongue, and floor of the mouth.” |
“Subjects received the PBM from the first day of the conditioning regimen and continued every day until the seventh post-transplant day [D+7].” |
| Martins et al., 2021 [22] | Head and neck cancer\ Radiotherapy, associated or not with chemotherapy. |
48 patients |
Placebo and preventative oral care program | InGaAlP diode laser | 660 nm | 6.2 J/cm2 | 10 s at each point | 25 mW | “Right and left buccal mucosa [10 points on each side], upper and lower labial mucosa [4 points each lip], hard palate [3 points], the lateral surface of the tongue [10 points on each side], soft palate [3 points], dorsal tongue [3 points], floor of the mouth [2 points], and labia commissure [one point on each side]” |
“The first session was performed on the first day of RT, and the following sessions occurred three times a week on alternate days, always before each session of RT until the end of the treatment.” |
PBM: photobiomodulation; RT: radiotherapy.