Table 4.
Comparison of the inter-method reliability of volumetric measurements across the three volumetry software packages.
| Lt. Hemisphere | Rt. Hemisphere | |||||
|---|---|---|---|---|---|---|
| NQ vs. FS | NQ vs. HAD | FS vs. HAD | NQ vs. FS | NQ vs. HAD | FS vs. HAD | |
| Cortical GM | ||||||
| Total | 0.945 (0.914–0.965) | 0.945 (0.914–0.965) | 0.945 (0.913–0.965) | 0.947 (0.916–0.966) | 0.944 (0.912–0.964) | 0.951 (0.923–0.969) |
| Non-AD | 0.939 (0.888–0.966) | 0.936 (0.884–0.965) | 0.954 (0.917–0.975) | 0.934 (0.880–0.964) | 0.932 (0.876–0.962) | 0.950 (0.910–0.973) |
| AD | 0.970 (0.939–0.985) | 0.876 (0.784–0.939) | 0.897 (0.791–0.949) | 0.990 (0.980–0.995) | 0.954 (0.909–0.977) | 0.974 (0.948–0.987) |
| Cerebral WM | ||||||
| Total | 1.000 (1.000–1.000) | 0.983 (0.973–0.989) | 0.983 (0.973–0.989) | 1.000 (1.000–1.000) | 0.978 (0.965–0.986) | 0.978 (0.965–0.986) |
| Non-AD | 1.000 (1.000–1.000) | 0.990 (0.982–0.995) | 0.990 (0.982–0.995) | 1.000 (1.000–1.000) | 0.988 (0.978–0.993) | 0.988 (0.978–0.993) |
| AD | 1.000 (1.000–1.000) | 0.972 (0.944–0.986) | 0.972 (0.944–0.986) | 0.996 (0.992–0.998) | 0.988 (0.976–0.994) | 0.986 (0.972–0.993) |
| Hippocampus | ||||||
| Total | 0.918 (0.871–0.948) | 0.724 (0.567–0.824) | 0.842 (0.753–0.899) | 0.917 (0.869–0.947) | 0.621 (0.406–0.759) | 0.807 (0.698–0.877) |
| Non-AD | 0.904 (0.826–0.947) | 0.600 (0.271–0.780) | 0.780 (0.599–0.879) | 0.886 (0.793–0.938) | 0.523 (0.132–0.738) | 0.784 (0.607–0.881) |
| AD | 0.914 (0.826–0.958) | 0.895 (0.787–0.948) | 0.892 (0.782–0.947) | 0.947 (0.892–0.974) | 0.835 (0.665–0.918) | 0.863 (0.723–0.932) |
| Amygdala | ||||||
| Total | 0.916 (0.869–0.947) | 0.897 (0.838–0.934) | 0.924 (0.881–0.952) | 0.892 (0.830–0.931) | 0.898 (0.840–0.935) | 0.936 (0.900–0.959) |
| Non-AD | 0.897 (0.812–0.943) | 0.888 (0.795–0.938) | 0.890 (0.800–0.940) | 0.844 (0.715–0.914) | 0.870 (0.762–0.928) | 0.923 (0.860–0.958) |
| AD | 0.909 (0.815–0.955) | 0.887 (0.772–0.944) | 0.967 (0.933–0.984) | 1.000 (1.000–1.000) | 0.998 (0.996–0.999) | 0.999 (0.998–0.999) |
| Caudate | ||||||
| Total | 0.876 (0.805–0.821) | 0.843 (0.753–0.900) | 0.899 (0.842–0.936) | 0.631 (0.420–0.764) | 0.850 (0.764–0.904) | 0.787 (0.666–0.864) |
| Non-AD | 0.856 (0.783–0.921) | 0.780 (0.600–0.879) | 0.883 (0.787–0.936) | 0.780 (0.600–0.879) | 0.835 (0.700–0.909) | 0.870 (0.764–0.929) |
| AD | 0.903 (0.804–0.952) | 0.880 (0.757–0.941) | 0.915 (0.828–0.958) | 0.999 (0.998–1.000) | 0.997 (0.995–0.999) | 0.998 (0.997–0.999) |
| Putamen | ||||||
| Total | 0.824 (0.724–0.888) | 0.840 (0.749–0.898) | 0.912 (0.862–0.944) | 0.853 (0.770–0.906) | 0.796 (0.680–0.870) | 0.947 (0.916–0.966) |
| Non-AD | 0.810 (0.655–0.896) | 0.821 (0.675–0.902) | 0.973 (0.851–0.985) | 0.760 (0.563–0.868) | 0.977 (0.958–0.987) | 0.801 (0.639–0.891) |
| AD | 0.728 (0.449–0.866) | 0.869 (0.734–0.935) | 0.762 (0.518–0.882) | 1.000 (0.999–1.000) | 0.998 (0.997–0.999) | 0.999 (0.997–0.999) |
| Pallidum | ||||||
| Total | 0.117 (−0.385–0.437) | 0.558(0.307–0.718) | 0.778 (0.651–0.858) | 0.077 (−0.447–0.412) | 0.370 (0.012–0.598) | 0.710 (0.546–0.815) |
| Non-AD | 0.036 (−0.754–0.470) | 0.613 (0.296–0.788) | 0.792 (0.622–0.886) | 0.365 (−0.156–0.651) | 0.381 (−0.126–0.660) | 0.916 (0.847–0.954) |
| AD | 0.419 (−0.177–0.713) | 0.446 (−0.122–0.726) | 0.446 (−0.122–0.726) | −0.045 (−1.116–0.484) | 0.573 (0.136–0.789) | 0.232 (−0.554–0.621) |
| Thalamus | ||||||
| Total | 0.954 (0.923–0.971) | 0.925 (0.882–0.952) | 0.974 (0.960–0.984) | 0.908 (0.855–0.941) | 0.899 (0.842–0.936) | 0.982 (0.972–0.989) |
| Non-AD | 0.956 (0.920–0.976) | 0.938 (0.886–0.966) | 0.978 (0.960–0.988) | 0.899 (0.815–0.944) | 0.907 (0.832–0.949) | 0.984 (0.971–0.991) |
| AD | 0.907 (0.812–0.954) | 0.791 (0.577–0.897) | 0.928 (0.854–0.964) | 1.000 (0.999–1.000) | 0.998 (0.996–0.999) | 0.999 (0.997–0.999) |
| Cerebellum | ||||||
| Total | 0.985 (0.977–0.990) | 0.944 (0.912–0.964) | 0.941 (0.908–0.963) | 0.978 (0.965–0.986) | 0.953 (0.927–0.970) | 0.964 (0.943–0.977) |
| Non-AD | 0.975 (0.955–0.986) | 0.909 (0.834–0.950) | 0.909 (0.834–0.950) | 0.969 (0.944–0.983) | 0.936 (0.883–0.965) | 0.934 (0.880–0.964) |
| AD | 0.988 (0.975–0.994) | 0.947 (0.892–0.974) | 0.942 (0.883–0.971) | 0.979 (0.957–0.990) | 0.954 (0.907–0.977) | 0.976 (0.952–0.988) |
Note—Data are presented as intraclass correlation coefficient (95% confidence interval); AD, Alzheimer’s disease; FS, FreeSurfer; GM, gray matter; HAD, Heuron AD; NQ, NeuroQuant; WM, white matter.