Table 2.
The oral microbiome, identified in the saliva samples of OSCC patients.
| S.NO | Sample (OSCC/Controls) | Method | Oral Microbiome | Ref. |
|---|---|---|---|---|
| 1 | USWS (45/45) | DNA-DNA hybridization | Capnocytophaga gingivalis, Prevotella melaninogenica and Streptococcus mitis, | [98] |
| 2 | SWS (3/2) | 16S rRNA PCR | Firmicutes and Bacteroidetes | [99] |
| 3 | USWS (6/25) | 16S rRNA PCR | Firmicutes, Streptococcus and Prevotella, Lactobacillus, Neisseria, Enterobacteriaceae, Oribacterium, Bacteroidetes and Proteobacteria | [100] |
| 4 | USWS (125/127) | 16S rRNA PCR | Bacillus, Enterococcus, Parvimonas, Peptostreptococcus, and Slackia | [101] |
| 5 | USWS (6/25) | 16S rRNA NGS | Lactobacillus gasseri, Lactobacillus johnsonii, and Fusobacterium_nucleatum | [102] |
| 6 | USWS (14/16) | 16S rRNA PCR | Prevotella, Neisseria, Rothia, Streptococcus and Veillonella | [103] |
| 7 | USWS (88/90) | 16S rRNA PCR | Prevotella tannerae, Fusobacterium nucleatum and Prevotella intermedia | [104] |
| 8 | USWS (6/4) | 16S rRNA PCR | Bacteroidetes and genus Solobacterium | [105] |
| 9 | SWS (60/80) | 16S rRNA PCR | Peptostreptococcus, Fusobacterium, Alloprevotella, and Capnocytophaga | [106] |
| 10 | USWS (10/15) | 16S rRNA PCR | Fusobacterium, Peptostreptococcus, and Prevotella, Streptococcus, Neisseria, and Haemophilus | [107] |
| 11 | USWS (31/23) | 16S rRNA PCR | Megasphaera, unclassified Enterobacteriae, Salmonella and Prevotella | [108] |
| 12 | USWS (56/64) | 16S rRNA PCR | Capnocytophaga and Neisseria | [109] |
| 13 | USWS (25/24) | 16S rRNA PCR | Prevotella, Fusobacterium, Porphyromonas, Streptococcus, Capnocytophaga, Haemophilus, Neisseria, Rothia, and Veillonella | [110] |
| 14 | USWS (59/32) | 16S rRNA NGS | Candida, Malassezia, Saccharomyces, Aspergillus, and Cyberlindnera | [111] |
| 15 | USWS (47/48) | 16S rRNA PCR | Actinobacteria, Fusobacterium, Moraxella, Bacillus, and Veillonella | [112] |
| 16 | USWS (23/18) | 16S rRNA PCR | Prevotella | [113] |
| 17 | USWS (16/8) | 16S rRNA PCR | Rothia, Veillonella, Staphylococcus, Centipeda, Dialister, Gemella, Granulicatella, Firmicutes and Actinobacteria | [114] |
| 18 | USWS (24/7) | 16S rRNA PCR | Prevotella, Chlamydia, Tissierellia, Calothrix, Leotiomycetes, Firmicutes and Zetaproteobacteria | [115] |
| 19 | USWS (99/101) | 16S rRNA PCR | Streptococcus anginosus, Abiotrophia defectiva, and Fusobacterium nucleatum | [116] |
S.NO—serial number, OSCC—oral squamous cell carcinoma, USWS—unstimulated whole saliva, SWS—stimulated whole saliva, DNA—deoxyribose nucleic acid, rRNA—ribosomal ribose nucleic acid, PCR—polymerase chain reaction.