Table 4.
List of genes found in the spleens of Riemerella anatipestifer-infected ducks related to Th17 differentiation.
| Expression | Gene | Description | Log2FC | FDR |
|---|---|---|---|---|
| DEG | ||||
| IL17A | Interleukin-17A | 9.34 | 0.01 | |
| IL17F | Interleukin-17F | 5.68 | 0.02 | |
| IL2RA | Interleukin-2 receptor subunit alpha | 3.38 | 0.02 | |
| IL1RAP | Interleukin 1 receptor accessory protein | 2.90 | 0.01 | |
| IFNGR2 | Interferon gamma receptor 2 | 1.63 | 0.04 | |
| IL1R1 | Interleukin 1 receptor type 1 | 1.54 | 0.04 | |
| NFKBIA | NF-kappa-B inhibitor alpha | 1.40 | 0.05 | |
| Upregulated | ||||
| GATA3 | GATA binding protein 3 | 2.30 | 0.33 | |
| IFNG | Interferon gamma | 2.30 | 0.18 | |
| CHUK | Component of inhibitor of nuclear factor kappa B kinase complex | 2.12 | 0.18 | |
| RORA | RAR related orphan receptor A | 1.65 | 0.39 | |
| HIF1A | Hypoxia inducible factor 1 subunit alpha | 1.62 | 0.23 | |
| JUN | Transcription factor AP-1 | 1.56 | 0.13 | |
| STAT1 | Signal transducer and activator of transcription 1 | 1.45 | 0.15 | |
| NFKBIE | NF-kappa-B inhibitor epsilon | 1.41 | 0.09 | |
| STAT3 | Signal transducer and activator of transcription 3 | 1.37 | 0.11 | |
| IL6ST | Interleukin-6 receptor subunit beta | 1.09 | 0.08 | |
| IL21R | Interleukin-21 receptor | 1.08 | 0.34 | |
| RXRA | Retinoic acid receptor RXR-alpha | 1.04 | 0.31 | |
| FOS | Proto-oncogene c-Fos | 0.93 | 0.29 | |
| IL2RB | Interleukin-2 receptor subunit beta | 0.93 | 0.53 | |
| IL6R | Interleukin-6 receptor subunit alpha | 0.76 | 0.46 | |
| MAPK11 | Mitogen-activated protein kinase 11 | 0.51 | 0.52 | |
| IL21 | Interleukin-21 | 0.42 | 0.86 | |
| MAPK14 | Mitogen-activated protein kinase 14 | 0.41 | 0.52 | |
| JAK2 | Tyrosine-protein kinase JAK2 | 0.27 | 0.86 | |
| PRKCQ | Protein kinase C theta type | 0.27 | 0.77 | |
| SMAD3 | SMAD family member 3 | 0.16 | 0.82 | |
| PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.08 | 0.94 | |
| ZAP70 | Tyrosine-protein kinase ZAP-70 | 0.01 | 0.99 | |
| Downregulated | ||||
| NFATC1 | Nuclear factor of activated T-cells, cytoplasmic 1 | −1.09 | 0.34 | |
| MAPK9 | Mitogen-activated protein kinase 9 | −0.83 | 0.30 | |
| LCK | Tyrosine-protein kinase Lck | −0.76 | 0.53 | |
| CD3E | T-cell surface glycoprotein CD3 epsilon chain | −0.45 | 0.76 | |
| CD247 | T-cell surface glycoprotein CD3 zeta chain | −0.44 | 0.73 | |
| PPP3CB | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform | −0.34 | 0.72 | |
| TGFBR1 | TGF-beta receptor type-1 | −0.30 | 0.83 | |
| IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | −0.28 | 0.72 | |
| MTOR | Serine/threonine-protein kinase mTOR | −0.25 | 0.80 | |
| JAK1 | Tyrosine-protein kinase JAK1 | −0.17 | 0.86 | |
| RUNX1 | Runt-related transcription factor 1 | −0.12 | 0.91 | |
| IFNGR1 | Interferon gamma receptor 1 | −0.08 | 0.96 | |
| MAPK12 | Mitogen-activated protein kinase 12 | −0.07 | 0.94 | |
| MAPK3 | Mitogen-activated protein kinase 3 | −0.07 | 0.94 | |
| PPP3R1 | Calcineurin subunit B type 1 | −0.07 | 0.94 |
FC = Fold change; FDR = false discovery rate.