Figure 5.

Tight junction signalling in response to L. rhamnosus KF7. Transcriptional information has been projected onto the KEGG tight junction pathway. For each gene, the left half represents the 4 h timepoint, and the right half represents the 8 h timepoint. Genes with increased expression in Caco-2 cells co-cultured with bacteria (compared to untreated Caco-2 cells at the given timepoint) are depicted in yellow (p < 0.05), decreased expression depicted in blue (p < 0.05), and no change in expression (p > 0.05) depicted in grey. Fold-changes >1.5 or <−1.5 are more intensely coloured. Pathway is a copyright of Kanehisa Laboratories, Kyoto University, Japan.