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. 2024 May 14;29(10):2296. doi: 10.3390/molecules29102296

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The solubility curves of ibuprofen (IP, left panel) and ketoprofen (KP, right panel) in aqueous DES mixtures at various temperatures, expressed as solvent-composition-related mole fractions. ChCl stands for eutectics with choline chloride, and BI stands for eutectics with betaine. x*_DES stands for mole fractions of solute-free DES in aqueous mixtures. For comparison, the room-temperature solubilities of IP in chloroform [94,95] and KP in methanol [96] are provided as reported in the literature.