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. 2024 May 22;8(6):e0444. doi: 10.1097/HC9.0000000000000444

FIGURE 3.

FIGURE 3

Effects of Fgf15 deficiency on liver injury indexes and energy metabolism in the serum and pathology. (A) Serum ALT, AST, and ALP activity levels. (B) Serum triglycerides, cholesterol, and BA levels; (C) Serum leptin and resistin levels in WT and Fgf15 ile−/− mice at preop, 1, 2, and 3 months postop. (D) Liver HE staining and (E) hepatic triglyceride and total cholesterol levels in WT and Fgf15 ile−/− mice in the preop state, 1, 2, and 3-month HFD-fed mice following SGx (n=4, 4, 6, 4 for WT, respectively; n=5, 6, 6, 8 for Fgf15 ile−/−, respectively). Representative liver H&E stains at ×100 magnification. $ is for statistical significance (p < 0.05) within the same genotype compared to preop control. # is for statistical significance (p<0.05) within the same time point. Abbreviations: ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BA, bile acid; H&E, hematoxylin and eosin; WT, wild type.