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. 2024 May 22;8(6):e0444. doi: 10.1097/HC9.0000000000000444

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Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Study of Liver Diseases.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/

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Effects of Fgf15 deficiency on BA-related gene expression in the intestine and liver with SGx. (A) Relative mRNA levels of ileal genes associated with BA transport and regulation; (B) relative mRNA levels of BA synthesis genes in the liver; (C) relative mRNA levels of liver genes associated with BA transport and regulation in both WT and Fgf15 ^ile−/− mice at preop state, 1, 2, and 3-month HFD-fed mice following SGx. (n=4, 4, 6, 4 for WT, respectively; n=5, 6, 6, 8 for Fgf15 ^ile−/−, respectively). $ is for statistical significance (p < 0.05) within the same genotype compared to preop control. # is for statistical significance (p < 0.05) within the same time point. Abbreviations: BA, bile acid; SGx, vertical sleeve gastrectomy; WT, wild-type.