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. 2024 May 22;8(6):e0444. doi: 10.1097/HC9.0000000000000444

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Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Study of Liver Diseases.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/

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Effects of Fgf15 deficiency on lipid-related gene expression in liver and BAT with SGx. (A) Relative mRNA levels of genes associated with lipid homeostasis; (B) relative mRNA levels of genes in BAT associated with adiposity and thermogenesis; (C) DCA and TDCA levels in the serum in both WT and Fgf15 ^ile−/− mice at preop state, 1, 2, and 3-month HFD-fed mice following SGx (n=4, 4, 6, 4 for WT, respectively; n=5, 6, 6, 8 for Fgf15 ^ile−/−, respectively). $ is for statistical significance (p < 0.05) within the same genotype compared to preop control. # is for statistical significance (p < 0.05) within the same time point. Abbreviations: DCA, deoxycholic acid; HFD, high-fat diet; SGx, vertical sleeve gastrectomy; TDCA, taurine-conjugated DCA; WT, wild type.