Table 1.
Baseline demographic and clinical characteristics of patients with ALK-positive non-small cell lung cancer.
| All patients | Gender | Smoking | |||||
|---|---|---|---|---|---|---|---|
| n = 367 | Male n = 201 |
Female n = 166 |
P | Absent (n = 185) |
Present (n = 154) |
P | |
| Median [IQR] | Median [IQR] | Median [IQR] | Median [IQR] | Median [IQR] | |||
| Age at diagnosis, years | 54 [46–62] | 57 [48–62] | 52 [43–62] | .099 | 52 [43–62] | 56 [48–62] | .07 |
| n (%) | n (%) | n (%) | n (%) | n (%) | |||
| Gender | <.001 | ||||||
| Female | 166 (42.2) | 130 (70.3) | 24 (15.6) | ||||
| Male | 201 (54.8) | 55 (29.7) | 130 (84.4) | ||||
| Smoking | 154 (45.4)* | 130 (64.7) | 24 (14.5) | <.001 | |||
| Asthma/COPD | 19 (5.2) | 5 (2.5) | 14 (8.4) | .01 | 13 (7) | 6 (3.9) | .21 |
| Family history of lung cancer | 32 (8.7) | 20 (10) | 12 (7.2) | .36 | 9 (4.9) | 23 (14.9) | .002 |
| Histology | .19 | .07 | |||||
| Adenocarcinoma | 357 (97.3) | 193 (96) | 164 (98.8) | 181 (97.8) | 149 (96.8) | ||
| NOS | 4 (1.1) | 2 (1) | 2 (1.2) | 3 (1.6) | – | ||
| Neuroendocrine | 3 (0.8) | 3 (1.5) | – | – | 3 (1.9) | ||
| Mixed | 3 (0.8) | 3 (1.5) | – | 1 (0.5) | 2 (1.3) | ||
| EGFR + | 2 (0.5) | 1 (0.5) | 1 (0.6) | 1 | 1 (0.5) | 1 (0.6) | 1 |
| ROS-1 + | 3 (0.8) | 3 (1.5) | – | .26 | – | 3 (1.9) | .09 |
| Symptoms | |||||||
| Cough | 195 (53.1) | 100 (49.8) | 95 (57.2) | .15 | 116 (62.7) | 74 (48.1) | .007 |
| Dyspnea | 177 (48.2) | 92 (45.8) | 85 (51.2) | .3 | 100 (54.1) | 73 (47.4) | .22 |
| Pain | 130 (35.4) | 70 (34.8) | 60 (36.1) | .79 | 71 (38.4) | 55 (35.7) | .61 |
| Weight loss | 103 (28.1) | 59 (29.4) | 44 (26.5) | .55 | 48 (25.9) | 53 (34.4) | .09 |
| Hemoptysis | 33 (9) | 21 (10.4) | 12 (7.2) | .28 | 11 (5.9) | 20 (13) | .03 |
| ECOG score at baseline | .34 | .13 | |||||
| 0 | 106 (28.9) | 60 (29.9) | 46 (27.7) | 49 (26.5) | 49 (31.8) | ||
| 1 | 169 (46) | 87 (43.3) | 82 (49.4) | 93 (50.3) | 68 (44.2) | ||
| ≥2 | 78 (21.3) | 44 (21.9) | 34 (20.5) | 39 (21.1) | 36 (23.3) | ||
Bold values indicate statistical significance at P < .05.
COPD = chronic obstructive pulmonary disease, ECOG = Eastern Cooperative Oncology Group, EGFR = epidermal growth factor receptor, IQR = inter-quartile range, NOS = not otherwise specified.
*
Because of missing data, percentages were reported over 339 patients who had complete data for smoking.