Figure 2.

(A) Time dependence of calcein leakage from mammalian-like (black curve) and fungal-like lipid vesicles (red curve) at the subsequent increase in the dose of POPC/CHOL/AmB formulation in bathing solution. The moments of addition of the formulation into the liposomal suspension are indicated by the arrows. The concentrations of the monomeric AmB in µM are shown above the arrows. (B) Time dependence of calcein leakage from fungal-like liposomes at the addition of antibiotic-free POPC/CHOL (blue curve) and POPC/CHOL/phloretin (olive curve) formulations. The addition of the formulations until the same volume concentration as antibiotic-loaded formulations in the bathing solution was carried out at the first moment.