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. 2024 May 16;16(5):665. doi: 10.3390/pharmaceutics16050665

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) The voltage dependence of the ratio of membrane conductance produced by one-side addition of the different phytosomes to conductance at zero transmembrane voltage (G/G₀): POPC/CHOL/AmB/phloretin (7, dark yellow curve), POPC/DESM/AmB/phloretin (11, wine curve), POPC/7DCHOL/AmB/phloretin (12, violet curve), POPC/CAMPO/AmB/phloretin (13, orange curve), POPC/STIGM/AmB/phloretin (14, dark cyan curve), and POPC/ERG/AmB/phloretin (15, dark grey curve). Inset: The time dependence of the alteration in the transmembrane current induced by formulation 7 at the voltage ramp from −200 to +200 mV per 5 s. (B) The voltage dependence of the ratio of membrane conductance produced by one-side addition of different Nys formulations to conductance at zero transmembrane voltage (G/G₀): POPC/CHOL/NyS (16, dark blue curve), POPC/ERG/NyS (17, olive curve), POPC/CHOL/NyS/phloretin (18, blue curve), and POPC/ERG/NyS/phloretin (21, green curve). Fungal-like lipid bilayers were bathed in 2.0 M KCl (pH 7.4).