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. 2024 May 10;21(5):e1004407. doi: 10.1371/journal.pmed.1004407

Table 1. Definitions of the statuses on the cyclical and linear HIV cascades.

Status on the cascade Definition
Cyclical cascade
HIV+ modelled Thembisa model estimate of those living with HIV in the province.
HIV+ diagnosed or HIV+ rediagnoseda Known with HIV based on digitised person-level evidence, without evidence of having died or migrated out of the province.
Linked to HIV care or Relinked to HIV careb Linked to HIV care based on digitised evidence of preparation for ART initiation, not yet started or restarted on ART.
Early ART or Early ART after restartc Started/restarted on ART less than 6 months previously and therefore not yet eligible for viral load assessment.
Long-term ART or Long-term ART after restartd Started/restarted ART at least 6 months previously and therefore expected to have had viral load assessed.
Disengagede Interrupted care for >90 days.
Linear cascade
HIV+ modelled Thembisa model estimate of those living with HIV in the province.
HIV+ identified Known with HIV based on digitised person-level evidence.
On ART On ART, based on current evidence of treatment in hand.
VL expected On ART, at least 6 months since naïve ART initiation.
VL done VL expected, and recent viral load done.
VL suppressedf VL expected with recent viral load done <1 000 copies/ml.
VL undetectable VL expected with recent viral load done <50 copies/ml.

a“HIV+ rediagnosed” describes a person who has disengaged at any point after initiating ART, i.e., was “Disengaged,” and then re-engaged by testing positive for HIV, but has not yet “Relinked to HIV care.”

bIn the era of same-day initiation, it is still possible to disengage between diagnosis and starting/restarting ART.

cA threshold of 6 months for “Early ART” was used in the context of guidelines recommending a first viral load assessment at 4 months. As newer guidelines recommend earlier assessment, it may be appropriate to reduce this threshold.

dLong-term ART statuses are further disaggregated by viral suppression sub-statuses.

eAn interruption threshold of 90 days was used in line with national reporting guidelines, i.e., >90 days with no visit for someone not previously on ART and >90 days without ART in hand for someone previously on ART.

fWhen calculating this as a percentage, the most appropriate denominator is VL expected, which consists of those people in the long-term ART status.

ART, antiretroviral therapy; VL, viral load.