Figure 2.

Genetic and antigenic summary of the analyzed SARS-CoV-2 Delta, Mu and Omicron variants. Spike mutations relative to the 614D reference virus (USA-WA1/2020) are shown with tables indicating the substitutions, insertions or deletions colored based on the spike protein domains. The reference amino acid at each position is labeled for the 614D reference at the top, and the amino acid changes are summarized at the bottom of the table. Residues with multiple different mutations are underlined. A dendrogram depicting the approximate relationships between analyzed variants has been added to the left of the mutation table. The variant names have been added to the right of the mutation table and are labeled by the parental virus with additional spike mutations relative to that parental virus. The antigenicity of all the analyzed variants are shown as neutralization fold change heatmaps colored from dark green, indicating a 0.5-fold change, to dark red, indicating a fold change of 194. Neutralization data using vaccinee sera post the primary series, monovalent third dose, and bivalent fourth dose are shown as fold change relative to 614D reference or the BA.4/5 variant.