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. 2024 May 15;16(5):784. doi: 10.3390/v16050784

Figure 2.

Figure 2

Identification of novel, potential brincidofovir/cidofovir antiviral resistance mutations in MPXV DNA polymerase (F8L) gene in the strains responsible for the 2022 mpox outbreak. A total of 230 MPXV F8L gene sequences were retrieved from whole genome sequences and aligned by ClustalW multiple alignment using BioEdit software, as reported elsewhere [46,47,48,49]. Among them, 110 and 120 sequences were isolated before and during the 2022 mpox outbreak, respectively. The consensus amino acid sequence of the F8L gene is shown at the top of the alignment. Although classic cidofovir resistance mutations [41] were not found among all MPXV sequences, 5 types of novel point mutations (R25Q (1/230), E45K (1/230), A102T (2/230), F108L (2/230), and R366K (3/230)) were identified among the 2022 mpox isolates (highlighted in red box).