Table 1.
Natural variations in the full-length Rev protein within individual HIV-1 group M clades.
| Clade a | Number of HIV-1 near Full-Length Genomes in the HIV Database | Number of Downloaded HIV-1 Sequences Used in Consensus | Number of Changes | Mean Changes per Sequence c |
Variable Positions (%) |
||
|---|---|---|---|---|---|---|---|
| Insertions (95→96 Site) b |
Deletions | Substitutions | |||||
| A1 | 805 | 245 | 7 (*) | 322 | 3374 | 15.1 | 89.4 |
| A6 | 222 | 187 | 6 (*) | 136 | 1664 | 9.6 | 82.1 |
| B | 10,974 | 1716 | 61 | 700 | 24,897 | 14.9 | 98.3 |
| C | 2420 | 865 | 58 (*) | 1435 | 9074 | 12.1 | 97.2 |
| D | 219 | 156 | 6 | 23 | 1534 | 10.0 | 79.3 |
| F1 | 79 | 74 | 29 | 4 | 942 | 12.8 | 70.7 |
| F2 | 14 | 14 | 2 | 2 | 160 | 11.4 | 48.3 |
| G | 101 | 91 | 4 (*) | 78 | 1343 | 15.6 | 75.6 |
| H | 10 | 10 | 1 | 0 | 135 | 13.5 | 46.5 |
| 01_AE | 2105 | 613 | 65 (*) | 777 | 6999 | 12.7 | 96.7 |
| 02_AG | 232 | 204 | 13 (*) | 424 | 2722 | 15.4 | 87.0 |
| 06_cpx | 25 | 17 | 0 | 6 | 167 | 10.2 | 47.4 |
| 07_BC | 46 | 40 | 0 (*) | 39 | 327 | 9.1 | 57.0 |
| 08_BC | 37 | 33 | 0 (*) | 8 | 191 | 6.0 | 49.5 |
| 11_cpx | 25 | 23 | 27 | 1 | 323 | 14.1 | 64.6 |
| 12_BF | 14 | 14 | 4 | 4 | 141 | 10.3 | 40.5 |
| 13_cpx | 10 | 10 | 1 (*) | 9 | 125 | 13.4 | 39.8 |
| 14_BG | 14 | 12 | 0 (*) | 0 | 68 | 5.7 | 29.3 |
| 22_01A1 | 21 | 15 | 0 (*) | 5 | 188 | 12.9 | 49.6 |
| 35_A1D | 22 | 22 | 0 (*) | 14 | 172 | 8.4 | 43.1 |
| 42_BF1 | 17 | 17 | 0 | 6 | 17 | 1.3 | 8.6 |
| 63_02A6 | 26 | 26 | 1 (*) | 7 | 187 | 7.5 | 47.1 |
| 71_BF1 | 14 | 14 | 0 | 0 | 163 | 11.6 | 44.8 |
| 85_BC | 11 | 11 | 1 (*) | 1 | 59 | 5.4 | 32.7 |
| 91_cpx | 10 | 10 | 0 | 0 | 34 | 3.4 | 21.5 |
| 103_01B | 10 | 10 | 0 (*) | 4 | 88 | 8.8 | 30.9 |
a Only HIV-1 subtypes or CRFs with more than 10 genomic sequences are listed. b HIV-1 subtypes or CRFs with insertions of seven amino acids between positions 95 and 96 of the Rev protein are marked with an asterisk. c Includes aa changes and deletions.