Figure 5.

Time of breakthrough infections (BTIs) in MM and controls in relation to occurrence of SARS-CoV-2 variants. Juxtaposition of the time of BTI and the relative abundance of circulating SARS-CoV-2 at that time, as deduced through the Austrian National SARS-CoV-2 Wastewater Monitoring, for which the influent of 48 wastewater treatment plants, serving ~60% of the Austrian population, are sampled. Relative abundance of variants of concern, following Pango nomenclature, is deduced by tiling whole-genome sequencing and variant deconvolution performed by the software tool VaQuERo [13]. Red dots indicate timepoints of BTIs in MM patients; green dots indicate time points of BTIs in control subjects.