Table 3.
Toxicokinetic characteristics of DON-3 sulphate after a single oral bolus administration of DON, OTA, and AFB1 whether combined or not with the algoclay-based decontaminant.
| Toxicokinetic Parameter | Mycotoxins | Mycotoxins + Algoclay-Based Decontaminant |
p-Value | SEM |
|---|---|---|---|---|
| AUC0–12h (response.h) | 760.9 b | 457.6 a | 0.01 | 92.9 |
| Cmax (response) | 346.1 | 270.1 | 0.48 | 105.0 |
| Tmax (h) | 1.31 | 0.91 | 0.25 | 0.33 |
| Relative F (%) | 100 | 60.1 |
a,b Values without a common letter within a row differ significantly (p < 0.05). SEM: standard error of the mean; AUC: area under the curve; Cmax: maximal plasma response; Relative F: relative oral bioavailability; Tmax: time at maximal plasma response. The experiment was carried out with eight repetitions, where each repetition represents one broiler chicken.