Table 3.
Variable | Studies | No. of Subjects (/Total, %) |
No. of Placebo (/Total, %) |
RR (95% CI) | Heterogeneity | ||
---|---|---|---|---|---|---|---|
I2 (95% CI) | τ2 (95% CI) | Q (p-Value) | |||||
Demographic data | |||||||
Age > 70/75 years | [48,51,52,80,81,82,83] | 19,316/51,055 (37.83%) |
19,216/50,876 (37.77%) |
1000 (0.984; 1.015) |
0.0% (0.0; 79.2) |
0.001 (0.001; 0.002) |
0.18 (0.996) |
White ethnicity | [48,51,52,80,81,82,83] | 38,034/51,055 (74.50%) |
37,975/50,876 (74.64%) |
0.996 (0.990; 1.003) |
0.0% (0.0; 79.2) |
0.001 (0.001; 0.002) |
2.09 (0.300) |
Male Gender | [48,51,52,80,81,82,83] | 25,386/51,055 (49.72%) |
25,056/50,876 (49.25%) |
1.024 (0.987; 1.061) |
71.2% (27.1; 88.6) |
0.001 (0.000; 0.056) |
13.89 (0.008) |
Comorbidities | |||||||
COPD | [48,51,52,82] | 3322/49,979 (6.65%) |
3379/50,148 (6.74%) |
0.986 (0.942; 1.033) |
0.0% (0.0; 84.7) |
0.001 (0.000; 0.024) |
0.38 (0.945) |
Congestive heart disease |
[48,51,52,82] | 802/49,979 (1.60%) |
815/50,148 (1.63%) |
0.986 (0.896; 1.086) |
0.0% (0.0; 84.7) |
0.001 (0.000; 0.015) |
0.38 (0.945) |
Asthma | [48,52,82] | 3000/32,576 (9.21%) |
2871/32,463 (8.84%) |
1.049 (0.999; 1.101) |
0.0% (0.0; 89.6) |
0.001 (0.000; 0.014) |
0.52 (0.772) |