Figure 5.

RBPs interacting with HPV16 3′ UTRs and polyadenylation sites. (A) RBPs that bind the HPV16 genome around the early polyadenylation site. Only the region of viral RNAs between the start of the E5 ORF and the end of the L2 ORF are shown in the diagram, which is not to scale. Open reading frames are shown by horizontal cylinders. Light grey region: early 3′UTR and polyadenylation site. Grey bar: upstream regulatory element in the early 3′ UTR. p(AE), early polyadenylation site. (B) RBPs that bind the late regulatory element (LRE: grey lozenge) in the HPV16 late 3′UTR. Only the L1 ORF is shown (not to scale). Green arrows, splicing regulation. Orange arrows, regulation of polyadenylation. RBPs not formally shown to bind the RNAs are shown in grey type.