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. 2024 May 20;12(5):559. doi: 10.3390/vaccines12050559

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The spike (S) protein was detected at the site of injection and draining lymph nodes, but not in the veins 1 day after intramuscular (IM) Ad26.COV2.S dosing in rabbits. (A) Rabbits (n = 40) were dosed with 5 × 10¹⁰ vp of Ad26.COV2.S, Ad26.S, Ad26.S.PP-PR, Ad26.Empty or 50 μg of S protein + Al(OH)₃. Anti-SARS-CoV2 S1 staining by immunohistochemistry of (B) muscle (administration site) and (C) draining lymph nodes (popliteal and iliac) at Day 1 (positive) and Day 11 postdosing (negative), and (D) lateral saphenous vein at Day 1 postdosing. In brown are the positive areas for the target protein. The black bar equals 100 μm.

The spike (S) protein was detected at the site of injection and draining lymph nodes, but not in the veins 1 day after intramuscular (IM) Ad26.COV2.S dosing in rabbits. (A) Rabbits (n = 40) were dosed with 5 × 10¹⁰ vp of Ad26.COV2.S, Ad26.S, Ad26.S.PP-PR, Ad26.Empty or 50 μg of S protein + Al(OH)₃. Anti-SARS-CoV2 S1 staining by immunohistochemistry of (B) muscle (administration site) and (C) draining lymph nodes (popliteal and iliac) at Day 1 (positive) and Day 11 postdosing (negative), and (D) lateral saphenous vein at Day 1 postdosing. In brown are the positive areas for the target protein. The black bar equals 100 μm.