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. 2024 May 24;12:RP91360. doi: 10.7554/eLife.91360

Figure 3. polygenic risk score (PR)S-based biobank-wide association scan (BWAS) identifies risk factors for Alzheimer’s disease (AD).

Meta-analysis p-values for 1738 heritable traits in the UK biobank are shown in the figure. p-values are truncated at 1e-15 for visualization purposes. The horizontal line marks the Bonferroni-corrected significance threshold (i.e. p=0.05/1738). Positive associations point upward, and negative associations point downward.

Figure 3.

Figure 3—figure supplement 1. Workflow of the two-stage biobank-wide association scan (BWAS) for late-onset Alzheimer’s disease (AD).

Figure 3—figure supplement 1.

Figure 3—figure supplement 2. Associations between Alzheimer’s disease (AD) and education attainment in two independent analyses.

Figure 3—figure supplement 2.

Error bars denote the standard error of effect estimates.