Table 2. Clinical characteristics, treatment modalities, and obstetric outcomes in pregnant patients with adult-onset Still's disease onset in pregnancy: a case series overview.

Case	Source reference	Age at Dx	Parity	Disease onset	Clinical presentations	Treatment	MOD	GA at delivery (wk)	Adverse obstetrical outcomes	Disease course	Postpartum
A01	Kaplinsky et al (1980) 42	34	G5P4	Unk	F, PA, R, SM, ↑ WBC	Gold	Unk	Unk	None	Polycyclic	Worsening of disease
A02	Green et al (1982) 43	23	Unk	Second tri	F, A, R, HM, SM	PDN	Unk	28	PTD, neonatal death due to prematurity	Polycyclic	Worsening of disease
A03	Yebra Bango et al (1985) 44	19	Unk	First tri	A, anorexia, HM, R, SM, ST	PDN	VD	Unk	None	Monocyclic	No flare-ups
A04	Le Loët et al (1993) 45	27	Unk	Second tri	A, F, LAD, pharyngitis, R	PDN	Unk	Unk	Transient Olig	Polycyclic	Unk
A05	Le Loët et al (1993) 45	30	Unk	First tri	Unk	PDN	Unk	Unk	Unk	Unk	Unk
A06	Le Loët et al (1993) 45	24	Unk	Second tri	A, F, LAD, pharyngitis, myalgias, R	PDN	VD	Unk	None	Polycyclic	Unk
A07	Falkenbach et al (1994) 46	25	G1P0	First tri	A, F, headache, myalgias, LAD, SM, HM, ST, ↑ WBC	IVIG, PDN	N/A	N/A	ETOP	Polycyclic	Unk
A08	Liozon et al (1999) 47	28	G1P0	First tri	F, LAD, PA, R, ST, ↑ WBC, ↑ Ferritin, ↑ AST/ALT	Salicylates 3 g/24 h, IVIG, PDN	C/S	36	PEC, placenta abruption, PTD	Polycyclic	Flare at 5 mo
A09	Pan et al (2003) 48	21	G2P1	Second tri	F, A, R, malaise, cough, headaches, myalgias, odynophagia, ↑ AST&ALT, ↑ Ferritin	PDN, HCQ	VD	34	IUGR (IOL)	Polycyclic	Persistence of symptoms
A10	Pan et al (2003) 48	38	G3P1	Second tri	F, A, malaise, cough, ST, ↑ ferritin	PDN	VD	FT	None	Monocyclic	No flare-ups
A11	Fischer-Betz et al (2011) 25	29	G2P1	First tri	F, PA, HM, pharyngitis, myalgias, SM, R, ↑WBC, ↑ Ferritin	PDN, anakinra	C/S	36	PTD	Polycyclic	Flare after few months
A12	Yamamoto et al (2012) 49	28	G0P0	Second tri	F, ST, LAD, R, PA, synovitis, pleural effusion, ↑ ferritin, ↑ WBC, ↑ AST and ALT	PSL, plasma exchange, cyclosporine, dexamethasone	C/S	33	HLH, oral ulcers induced by CMV, IUGR	Monocyclic	No flare-ups
A13	Hammami et al (2013) 50	32	G1P0	Second tri	F, PA, R, SM, weight loss, ↑ ferritin	PDN	VD	34	PTD	Monocyclic	No flare-ups
A14	Gerfaud-Valentin et al (2014) 51	33	Unk	First tri	F, erythema, LAD, PA, ↑ WBC	PDN	Unk	34	PPROM	Polycyclic	Flare at 1 mo
A15	Gerfaud-Valentin et al (2014) 51	27	Unk	Second tri	F, PA, erythema, SM	PDN + IVIG + NSAIDs	Unk	32	PTD, oligo	Polycyclic	Flare at 1 and 3 mo
A16	Gerfaud-Valentin et al (2014) 51	36	Unk	Second tri	F, PA, erythema, pharyngitis, LAD, SM	PDN	Unk	FT	None	Monocyclic	Unk
A17	Moussa and Hassan (2014) 52	25	G1P0	Second tri	F, A, malaise, HM, SM, ↑ WBC, ↑ ferritin	PDN	Unk	Unk	Unk	Unk	Unk
A18	Odai et al (2015) 53	32	Unk	Second tri	F, R, LAD, PA, ST, ↑ WBC, ↑ ferritin	PSL, LCAP twice weekly × 12 wk	C/S	34	PPROM	Monocyclic	No flare-ups
A19	Lin et al (2016) 16	Unk	Unk	Third tri	F, A, HM, SM, R, LAD, TTP	Unk	Unk	Unk	PTD, neonatal HLH	Unk	Unk
A20	Nakamura et al (2016) 28	22	G1P0	Second tri	F, R, PA, ↑WBC, ↑ferritin	PSL, tacrolimus	Unk	38	None	Monocyclic	No flare-ups
A21	Plaçais et al (2018) 54	38	Unk	First tri	F, myalgias, PA, HM, ST, ↑ ferritin, ↑ AST and ALT	PDN, colchicine, IVIG	Unk	34	Acute agranulocytosis (related to colchicine) c/b severe sepsis	Polycyclic	Disease persisted despite delivery and sepsis control; addition of anakinra allowed rapid remission
A22	Present case	29	G3P2	Second tri	F, headaches, vomiting, ↑AST and ALT	Methylprednisolone, azathioprine, anakinra	C/S	32	HLH, acute agranulocytosis (related to anakinra) c/b severe sepsis, placental abruption, GDM	Polycyclic	No flare-ups

Abbreviations: A, arthralgia/arthritis; ALT, alanine aminotransferase; AST, aspartate aminotransferase; C/S, cesarean section; CMV, cytomegalovirus; CS, corticosteroids; Dx, diagnosis; ETOP, elective termination of pregnancy; F, fever; FT, full-term; GDM, gestational diabetes mellitus; HCQ, hydroxychloroquine; HLH, hemophagocytic lymphohistiocytosis; HM, hepatomegaly; IOL, induction of labor; IUFD, intrauterine fetal demise; IVIG, intravenous immunoglobulin; LAD, lymphadenopathy; LCAP, leukocytapheresis; MOD, mode of delivery; N/A, not applicable; NSAIDs, nonsteroidal anti-inflammatory drugs; Olig, oligohydramnios; PA, polyarthralgia/polyarthritis; PDN, prednisone; PSL, prednisolone; PTB, preterm birth; PTD, preterm delivery; R, rash; SM, splenomegaly; ST, sore throat; tri, trimester; Unk, unknown; VD, vaginal delivery; WBC, white blood cell count.