Table 3.

ADC measurements and response assessment

Study	R: pre-ADC	NR: pre-ADC	R: post-ADC	NR: post-ADC	R: ADC increase	NR: ADC increase	Response assessment	Diagnostic performance
								Criteria	Sensitivity/specificity
Cuneo KC, et al [23]	1.61 ± 0.05	1.25 ± 0.16	ND	ND	ND	ND	Pre-ADC correlates with pathological response grade	NA	NA
Dalah E, et al [24]	ND	ND	ND	ND	ND	ND	Post-ADC correlates with pathological response	NA	NA
Hussien N, et al [12]	1.0 (1.0–1.3)	1.4 (1.0–1.4)	1.4 (1.3–1.7)	1.3 (1.0–1.7)	ND	ND	ADC increase in responders	Stationary vs. regressive ADC	100%/94.7%
Kang JH, et al [14]	1.46 ± 0.23	1.40 ± 0.19	ND	ND	14.9 ± 13.8%	10.3 ± 27.6%	No significant differences in ADC	NA	NA
Kinh Do R, et al [25]	1.60 ± 0.17	1.50 ± 0.05	ND	ND	ND	ND	No significant differences in ADC	NA	NA
Okada KI, et al (2017) [26]	ND	ND	ND	ND	ND	ND	Pre- and post-ADC correlate with pathological response grade	Pre-ADC (≥ 1.2)	100%/75%
Okada KI, et al (2020) [13]	ND	ND	ND	ND	ND	ND	Pre-ADC, post-ADC, and ADC increase correlate with pathological response grade	Pre-ADC (≥ 1.2)	91.6%/62.5%
								Post-ADC (≥ 1.4)	100%/81%

R, responders; NR, non-responders; pre-ADC, ADC value pre-neoadjuvant therapy; post-ADC, ADC value post-neoadjuvant therapy; ND, non-disclosed; NA, not assessed. ADC values (× 10⁻³ mm²/s) are expressed as means ± standard deviations or medians and ranges (in parentheses)