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. 2024 Feb 21;60(5):449–465. doi: 10.1007/s11626-024-00855-w

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© The Author(s) 2024

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Figure 2. — Ubiquitin-dependent proteolysis governs Wnt signaling. A large number of ubiquitin ligases (shown in red) and deubiquitinating enzymes (shown in blue) quantitatively and qualitatively regulate most of the effectors that are involved in Wnt signaling. Multiple ligases and deubiquitinating enzymes are assigned to each effector. Some other enzymes for ubiquitin-dependent modification may also have been identified, but not all are shown here.