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Chemical structures of various nitrosamine impurities and nitrosamine drug substance-related impurities (NDSRIs). NDMA: N-nitrosodimethylamine; NDEA: N-nitrosodiethylamine; NMBA: N-nitroso-N-methyl-4-aminobutanoic acid; NDBA: N-nitrosodibutylamine; MeNP: 1-methyl-4-nitrosopiperazine; NNV: N-nitroso-varenicline; NMOR: N-nitrosomorpholine; NIPEA: N-nitrosoisopropylethyl amine; NDIPA: N-nitrosodiisopropylamine; NMPA: N-nitrosomethylphenylamine.
