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. 2024 May 7;27(6):109920. doi: 10.1016/j.isci.2024.109920

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© 2024 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Activation of CB1 receptor enhances scotopic ERG wave amplitudes in the rat retina

(A) ERG sample traces before (left, top) and after the intravitreal injection of WIN (1 μM, n = 8 animals, left, bottom). CB1R activation increased b-wave amplitude independently of light intensity (middle), while a-wave amplitude increased only during high light intensity stimulation (right).

(B) ERG sample traces before and after the co-application of WIN and AM251 (4 μM, n = 9 animals, left). Note that the co-application of WIN and AM251 eliminated the WIN-mediated effects on the ERG b-wave (middle) but did not prevent the increase in the ERG a-wave (right). Data are presented as mean ± S.E.M and open circles represent a single animal. ∗p < 0.05. Comparisons were made using paired t-tests or Wilcoxon signed-rank tests. For statistics, see Table S1.