Figure 7.

CB1 receptor activation prolongs dim-light ERG b-wave in a GABAR-dependent manner

(A) Normalized ERG b-waves recorded at dim light intensities (left) and summary graph (right) showing that WIN (1 μM) prolongs the decay time course of the b-wave at dim light intensities (n = 8 animals).

(B) ERG sample traces before (black) and after the intravitreal injection of a cocktail of WIN and GABAR antagonists TPMPA (10 μM) and SR95531 (5 μM, gray). Note that when both GABA_A and GABA_C receptor blockers where co-applied, WIN no longer affected the amplitude of the ERG b-wave (right).

(C) Blocking GABA receptors eliminated the changes in the ERG b-wave kinetics (n = 5 animals). Data are presented as mean ± S.E.M and open circles represent a single animal. ∗p < 0.05, ∗∗p < 0.01. Comparisons were made using Paired t-tests or Wilcoxon signed-rank tests. For statistics, see Table S1.