Table 1.
Specificity and sensitivity analysis of the CZV1-1 assay on a large panel (n = 226) of ZIKV-naive and ZIKV-immune samples
| Results with conventional assays | Binding to CZV1-1 | |||||
|---|---|---|---|---|---|---|
| ZIKV | DENV | YFV* | CHIKV | Sera tested | Sera positive | %Sera positive |
| − | − | − | − | 61 | 1 | 1.6% |
| − | + | − | − | 55 | 2 | 3.6% |
| − | − | + | − | 5 | 0 | 0% |
| − | − | − | + | 5 | 0 | 0% |
| Total ZIKV negatives | 192 | 3 | 1.6% | |||
| + | − | − | − | 5 | 5 | 100% |
| + | + | − | − | 29 | 24 | 82.7% |
| Total ZIKV positives | 34 | 29 | 85.3% | |||
ZIKV: Zika virus, DENV: dengue viruses, CHIKV: chikungunya virus, YFV: yellow fever virus.
*Samples from YFV vaccinees.