Table 3.
Multivariable Cox regression analysis of variables associated with lesion local control for treated lesions
| Clinical variable | HR (95% CI) | P value |
|---|---|---|
| PSMA response* | 1.003 (1.001-1.006) | 0.016 |
| BED3 (continuous) | 0.97 (0.96-0.99) | 0.005 |
| Lymph node (vs bone) | 1.44 (0.29-7.15) | 0.7 |
| Concurrent ADT (vs no ADT) | 0.19 (0.03-1.07) | 0.06 |
| Pre-MDT SUVmax (continuous) | 1.04 (1.01-1.06) | 0.002 |
Abbreviations: ADT = androgen deprivation therapy; BED3 = biologically effective dose (α/β = 3); MDT = metastasis-directed therapy; PSMA = prostate-specific membrane antigen; SUV = standardized uptake value.
⁎
PSMA response defined as percent change in SUVmax after MDT, evaluated as a continuous variable.