Figure 3.

Silencing of hCHST15 siRNA alters stromal components in human BxPC-3 and mouse KPC models

(A and B, top) Immunostaining for CHST15, citrullinated histone H3 (Citrullinated H3), CD3 or mLy6C/G (brown) and Sirius red in the tumor of mice treated with vehicle control or hCHST15 siRNA. Scale bars, 20 μm. Yellow arrows indicate positive signals. (A and B) Quantitative analysis for stained tissues. Percentage positive areas for CHST15, Sirius red, citrullinated H3, CD31, and mLy6C/G are shown. Mean ± SD (n = 5). ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001 by Wilcoxon rank-sum test.