Figure 2.

Comparison of kidney function at follow-up based on race and APOL1 status of the participants using race-neutral CKD-EPI 2021 creatinine-cystatin C GFR calculator. eGFR (mL/min/1.73 m²) calculated using the CKD-EPI 2021 calculator using creatinine and cystatin was used to assess kidney function at follow-up. (A) At 10 years of follow-up, White participants had lower mean eGFRcr-cys than low-risk and high-risk groups (P < 0.01). (B) At 25 years of follow-up, eGFRcr-cys was lower in White participants than Black participants with the low-risk APOL1 genotype (P < 0.01), and there was no difference between Black participants in the low- and high-risk groups. (C) At 30 years of follow-up, there was no difference in eGFRcr-cys among the 3 groups. The box plot indicates median and interquartile range. eGFRcr-cys, creatinine- and cystatin C-based estimated glomerular filtration rate; GFR, glomerular filtration rate.