Table 2.
Raw diagnostic accuracy data of studies included in meta-analysis.
| Tech | Author | TP | FP | TN | FN | Total | Sensitivity | Specificity | PPV | NPV | Accuracy |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SR | Lin et al. [45] | 24 | 10 | 158 | 13 | 205 | 64.9 | 94.1 | 70.6 | 92.4 | 88.8 |
| Bathla et al. [46] | 24 | 5 | 56 | 102 | 187 | 58.5 | 91.8 | 82.8 | 76.7 | 78.4 | |
| Baù et al. [47] | 2 | 0 | 15 | 1 | 18 | 66.7 | 100 | 100 | 93.8 | 94.4 | |
| Chagpar et al. [48] | 12 | 12 | 44 | 90 | 158 | 41.2 | 78.6 | 53.9 | 68.8 | 64.4 | |
| Chand et al. [49] | 4 | 2 | 22 | 2 | 30 | 66.7 | 91.7 | 66.7 | 91.7 | 86.7 | |
| Ciccarelli et al. [50] | 25 | 9 | 55 | 102 | 191 | 65.8 | 85.9 | 73.5 | 80.9 | 41.8 | |
| Coombs et al. [51] | 12 | 4 | 25 | 52 | 93 | 52.2 | 86.2 | 75 | 69.4 | 39.8 | |
| Funk et al. [52] | 114 | 331 | 2179 | 196 | 2820 | 36.8 | 86.8 | 25.6 | 91.8 | 81.3 | |
| Graham et al. [53] | 62 | 1 | 18 | 119 | 200 | 62 | 95 | 98 | 32 | 67.2 | |
| Hisada et al. [54] | 6 | 6 | 106 | 23 | 141 | 20.7 | 94.6 | 50 | 82.2 | 79.4 | |
| Kulkarni et al. [55] | 23 | 123 | 538 | 24 | 708 | 48.9 | 81.4 | 15.8 | 95.7 | 79.2 | |
| McCormick et al. [56] | 6 | 10 | 72 | 93 | 181 | 54.6 | 87.8 | 37.5 | 93.5 | 83.9 | |
| Miller et al. [57] | 2 | 2 | 16 | 2 | 22 | 50 | 88.9 | 50 | 88.9 | 81.8 | |
| Park et al. [58] | 14 | 61 | 24 | 0 | 99 | 100 | 28.2 | 18.7 | 100 | 38.4 | |
| Pop et al. [12] | 4 | 11 | 63 | 5 | 83 | 44.4 | 85.1 | 26.7 | 92.7 | 80.7 | |
| Prueksadee et al. [59] | 3 | 3 | 1 | 12 | 19 | 37.5 | 25 | 50 | 16.7 | 33.3 | |
| Saarela et al. [60] | 9 | 8 | 31 | 66 | 114 | 33 | 79 | 53 | 63 | 61 | |
| Schaefgen et al. [61] | 13 | 62 | 87 | 12 | 174 | 52 | 58.4 | 17.3 | 87.9 | 57.5 | |
| Stachs et al. [62] | 34 | 16 | 67 | 0 | 117 | 70 | 56.7 | 54.7 | 71.7 | 62.4 | |
| Weber et al. [13] | 12 | 6 | 9 | 35 | 62 | 60 | 60 | 66.7 | 52.9 | 60 | |
| OPT | Brown et al. [63] | 27 | 7 | 14 | 7 | 55 | 79.4 | 66.7 | 79.4 | 66.7 | 74.6 |
| Keller et al. [64] | 29 | 6 | 139 | 5 | 179 | 85.3 | 95.9 | 82.9 | 96.5 | 94 | |
| Nguyen et al. [65] | 9 | 2 | 9 | 0 | 20 | 100 | 81.8 | 81.8 | 100 | 90 | |
| Schmidt et al. [66] | 11 | 1 | 32 | 6 | 50 | 64.7 | 97 | 91.7 | 84.2 | 86 | |
| Zhu et al. [67] | 222 | 26 | 454 | 18 | 720 | 92.5 | 94.6 | 89.5 | 96.2 | 93.9 | |
| MP | Hoffman et al. [68] | 3 | 97 | 192 | 10 | 302 | 23.1 | 66.4 | 3 | 95.1 | 64.6 |
| Karni et al. [69] | 30 | 88 | 184 | 12 | 314 | 71.4 | 67.7 | 25.4 | 93.9 | 68.2 | |
| LeeVan et al. [70] | 17 | 32 | 10 | 1 | 60 | 94.4 | 23.8 | 34.7 | 90.9 | 45 | |
| MCT | McClatchy et al. [71] | 3 | 9 | 18 | 2 | 32 | 60 | 66.7 | 25 | 90 | 65.6 |
| Qiu et al. [35] | 5 | 0 | 20 | 4 | 29 | 55.6 | 100 | 100 | 83.3 | 86.2 | |
| Tang et al. [36] | 5 | 1 | 18 | 1 | 25 | 83.3 | 94.7 | 83.3 | 94.7 | 92 | |
| IOUS | Kumar et al. [15] | 16 | 0 | 46 | 0 | 62 | 100 | 100 | 100 | 100 | 100 |
| Londero et al. [72] | 8 | 24 | 132 | 20 | 184 | 28.6 | 84.6 | 25 | 86.8 | 76.1 | |
| Mesurolle et al. [73] | 30 | 8 | 33 | 10 | 81 | 75 | 80.5 | 79 | 76.7 | 77.8 | |
| Moschetta et al. [74] | 16 | 6 | 90 | 20 | 132 | 44.4 | 93.8 | 72.7 | 81.8 | 80.3 | |
| Perera et al. [75] | 5 | 26 | 349 | 4 | 384 | 55.6 | 93.1 | 16.1 | 98.9 | 92.2 | |
| Pop et al. [12] | 8 | 25 | 49 | 1 | 83 | 88.9 | 66.2 | 24.2 | 98 | 68.7 | |
| Ramos et al. [76] | 24 | 79 | 116 | 6 | 225 | 80 | 59.5 | 95.1 | 23.3 | 62.2 | |
| FS | Caruso et al. [77] | 5 | 3 | 44 | 1 | 53 | 83 | 93 | 62 | 97 | 94 |
| Ikeda et al. [78] | 17 | 4 | 34 | 1 | 56 | 94.4 | 89.5 | 81 | 97.1 | 91.1 | |
| Jorns et al. [79] | 12 | 0 | 28 | 6 | 46 | 66.7 | 100 | 100 | 82.4 | 87 | |
| Kikuyama et al. [80] | 287 | 18 | 440 | 18 | 763 | 94.1 | 96.1 | 94.1 | 96.1 | 95.3 | |
| Kim et al. [81] | 3 | 1 | 23 | 2 | 29 | 60 | 95.8 | 75 | 92 | 89.7 | |
| Ko et al. [82] | 120 | 1 | 338 | 24 | 483 | 83.3 | 99.7 | 99.2 | 93.4 | 94.8 | |
| Kumar et al. [15] | 10 | 0 | 46 | 6 | 62 | 62.5 | 100 | 100 | 88.5 | 90.3 | |
| Mahadevappa et al. [14] | 33 | 1 | 28 | 0 | 62 | 100 | 96.6 | 97.1 | 100 | 98.4 | |
| Noguchi et al. [83] | 23 | 12 | 64 | 1 | 100 | 95.8 | 84.2 | 65.7 | 98.5 | 87 | |
| Nowikiewicz et al. [84] | 4 | 0 | 429 | 72 | 505 | 5.3 | 100 | 100 | 85.6 | 85.7 | |
| Olson et al. [85] | 57 | 5 | 1228 | 21 | 1311 | 73.1 | 99.6 | 91.9 | 98.3 | 98 | |
| Osako et al. [86] | 259 | 53 | 955 | 60 | 1327 | 81.2 | 94.7 | 83 | 94.1 | 91.5 | |
| Rusby et al. [87] | 39 | 15 | 495 | 8 | 557 | 83 | 97 | 72.2 | 98.4 | 96 | |
| Weber et al. [13] | 32 | 5 | 35 | 8 | 80 | 80 | 87.5 | 86.5 | 81.4 | 83.8 | |
| CYT | Bakhshandeh et al. [88] | 30 | 7 | 472 | 1 | 510 | 97 | 99 | 81.1 | 99.8 | 98.4 |
| Blair et al. [89] | 3 | 0 | 115 | 1 | 119 | 75 | 100 | 100 | 99.1 | 99.2 | |
| Cox et al. [90] | 22 | 3 | 86 | 0 | 111 | 100 | 96.6 | 88 | 100 | 97.3 | |
| Creager et al. [91] | 12 | 18 | 104 | 3 | 137 | 80 | 85.3 | 40 | 97.2 | 85 | |
| D'Halluin et al. [92] | 71 | 26 | 304 | 9 | 410 | 88.6 | 92.2 | 73.6 | 97 | 91.5 | |
| Ku et al. [93] | 17 | 2 | 68 | 0 | 87 | 100 | 97.1 | 89.5 | 100 | 97.7 | |
| Mahadevappa et al. [14] | 33 | 1 | 27 | 0 | 61 | 100 | 96.4 | 97.1 | 100 | 98.4 | |
| Muttalib et al. [94] | 6 | 6 | 15 | 0 | 27 | 100 | 71.4 | 50 | 100 | 77.8 | |
| Sumiyoshi et al. [95] | 14 | 4 | 136 | 6 | 160 | 70 | 97.1 | 77.8 | 95.8 | 93.8 | |
| Tamanuki et al. [96] | 78 | 58 | 375 | 11 | 522 | 87.6 | 86.6 | 57.4 | 97.2 | 86.8 | |
| Tohnosu et al. [97] | 27 | 16 | 156 | 1 | 200 | 96.4 | 90.7 | 62.8 | 99.4 | 91.5 | |
| Valdes et al. [98] | 1 | 1 | 59 | 11 | 72 | 8.3 | 98.3 | 50 | 84.3 | 83.3 | |
| Valdes et al. [99] | 3 | 11 | 53 | 1 | 68 | 75 | 82.8 | 21.4 | 98.2 | 82.4 |
Tech, technique; SR, Specimen Radiography; OPT, Optical Spectroscopy; CYT, Cytology; IOUS, Intraoperative Ultrasound; FS, Frozen Section; MP, Margin Probe; MCT, Micro Computerised Topography; TP, true positive; FP, false positive; TN, true negative; FN, false negative; PPV, positive predictive value; NPV, negative predictive value; Accuracy, diagnostic accuracy.