Table 3.
Multistate Models Evaluating Factors Associated With LTFU and Reengagement
| Engaged to LTFU | Reengaged to LTFU | LTFU to Reengaged | |
|---|---|---|---|
| Age (per 10 y) | 0.76 (95% CI, .71–.81) | 0.81 (95% CI, .72–.9) | 0.86 (95% CI, .79–.94) |
| Indigenous | 1.09 (95% CI, .91–1.29) | 1.88 (95% CI, 1.49–2.4) | 1.28 (95% CI, 1.04–1.59) |
| Sex (ref: male) | |||
| Female | 0.99 (95% CI, .85–1.15) | 0.97 (95% CI, .78–1.2) | 0.87 (95% CI, .73–1.04) |
| Men who have sex with men (ref: Men) | 1.14 (95% CI, .96–1.34) | 1.11 (95% CI, .86–1.4) | 1.01 (95% CI, .82–1.23) |
| Income (<$1500/m) (ref: ≥$1500/m) | 1.02 (95% CI, .89–1.17) | 0.97 (95% CI, .79–1.2) | 0.84 (95% CI, .72–.99) |
| PWID | 1.09 (95% CI, .95–1.26) | 0.92 (95% CI, .74–1.10) | 1.10 (95% CI, .94–1.30) |
| Incarceration | 1.94 (95% CI, 1.58–2.40) | 1.45 (95% CI, .98–2.1) | 0.90 (95% CI, .69–1.19) |
| HCV RNA (ref: undetectable) | |||
| HCV RNA (detectable) | 1.37 (95% CI, 1.13–1.67) | 0.99 (95% CI, .73–1.3) | 1.19 (95% CI, .94–1.50) |
| HCV RNA (not done) | 0.97 (95% CI, .80–1.16) | 1.04 (95% CI, .80–1.4) | 1.45 (95% CI, 1.17–1.79) |
| HIV viral load (<50 copies/mL) (ref: ≥ 50) | 1.02 (95% CI, .88–1.17) | 0.83 (95% CI, .66–1.0) | 0.98 (95% CI, .83–1.17) |
| CD4 (per 100 cells/mm3) | 0.99 (95% CI, .98–1.01) | 1.05 (95% CI, 1.02–1.1) | 1.04 (95% CI, 1.01–1.06) |
| Significant liver fibrosis (APRI >1.5) | 0.76 (95% CI, .63–0.91) | 1.24 (95% CI, .91–1.7) | 0.88 (95% CI, .71–1.09) |
| STI | 1.00 (95% CI, .76–1.32) | 0.76 (95% CI, .45–1.3) | 1.20 (95% CI, .85–1.68) |
| HCV Treatment (ref: SVR) | |||
| Treated but unknown SVR result | 1.99 (95% CI, 1.58–2.40) | 1.80 (95% CI ,1.23–2.6) | 1.03 (95% CI, .77–1.37) |
| No history of treatment | 1.29 (95% CI, 1.09–1.52) | 1.38 (95% CI, 1.11–1.7) | 0.63 (95% CI, .52–.77) |
| Failed | 0.83 (95% CI, .61–1.13) | 0.92 (95% CI, .61–1.4) | 0.58 (95% CI, .41–.83) |
Bold results indicate clinical or statisitcal significant results. Abbreviations: APRI, AST to platelet ratio index; CI, confidence interval; HCV, hepatitis C virus; LTFU, lost to follow-up; SVR, sustained virologic response. Results are adjusted hazards ratio, (95% confidence interval (CI)).