Figure 5.

Effect of CD38 KO on retinal glial cell activation in mice in the ONC model. (A) GFAP immunofluorescence staining of mouse retinal flat preparations. (B) Quantitative statistics of mouse retinal flat preparations GFAP immunofluorescence staining. (C) The expression of GFAP protein in retina was detected by WB in sham operation group and crush on day 3, day 7, and day 14. (D) WB was used to detect changes in CD38 protein expression in the retina of sham and crush 7 day groups in WT and KO mice. The red arrow = activation of the macroglia, Scale bars = 50 µm; WT, wild type; KO, knockout; data presented as mean ± SEM. **P < 0.01, ***P < 0.001.