Table 1.

Criteria of treatment-resistant definitions

Criteria of treatment-resistant definitions
Low cut-off	Non-response or intolerant to antipsychotics without a specification and studies that do not meet intermediate or high cut-off criteria
Intermediate cut-off	Failure of response to at least 2 trials with antipsychotics at dosage in the therapeutic range and adequate duration and persistent at least moderate symptoms assessed with standardized rating scales
High cut-off	Failure of response to at least two antipsychotic drug trials at dosage in the therapeutic range and adequate duration and at least one of them was prospective, also persistent at least moderate symptoms assessed with standardized rating scales at an assessment at the end of the prospective trial