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. 2024 May 25;8:120. doi: 10.1038/s41698-024-00613-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Odds ratios (abbreviated as OR) and confidence intervals were plotted, compared to 414 PCAWG typical cancer patients. Different regimens, combinations of therapies, were labeled by different colors. NEER_C (n = 7), NEER_RC (n = 10) and NEER_RCT (n = 7) refer to chemotherapy only, a combination of radiation therapy and chemotherapy, and a combination of radiation therapy, chemotherapy and targeted therapy respectively among NEER ERs. NEER_Others refers to the group of ERs with other combinations of therapies. Each specific combination has a sample size less than 7. b ERs in NEER (n = 7) and patients in PCAWG (n = 52) treated only by chemotherapy were subsetted. Boxplots showed the distributions of their PRSs in different autoimmune diseases. c ERs in NEER (n = 10) and patients in PCAWG (n = 11) treated by both chemotherapy and radiation therapy were subsetted. Boxplots showed the distributions of their PRSs in different autoimmune diseases. The histological cancer types were labeled through the shapes of dots. * signifies p < 0.05 **p < 0.01 ***p < 0.001.